Abstract
A novel metal nanoparticles@mesoporous silicas with high surface area (≈ 300 m2g−1), large pore size (≫ 5.0 nm) and high metal nanoparticles content (≈ 10 wt.%) have been prepared and used as surface enhanced matrix for bacteria charectization under Raman scattering analysis. The prepared nanoparticles@mesoporous silicas present great adhesion ability to direct contact with microorganism, i.e. S. aureus. The characterized peak at 1523 cm−1 can be gradually enhanced from original 200 counts to 1000 and 4000 counts when Au content increased to 6% and 4%, respectively.