2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
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Abstract

It is well known that gout and hyperuricemia are comorbidity due to the high level of uric acid in the blood and its crystallization. However, the pathological mechanism underlying the comorbidity of gout and hyperuricemia is still obscure. In this study, focused on the genes associated with hyperuricemia and gout, three functional protein networks were constructed. They illustrate the pathological mechanism of comorbidity via directed protein regulations from gout to hyperuricemia, vice versa, and their union. Accordingly, these networks contain 8 proteins associated with gout and hyperuricemia, 11 internal proteins bridging their inter-regulations. Consequently, enrichment analysis reveal that these participant proteins mainly functions in processes of immune responses and purine metabolisms. What's more, these participant proteins were primarily validated with PubMed literature and confirmed by bioinformatics tools.
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