Abstract
The high degree of complexity in cellular and circuit structure of the brain poses challenges for understanding tissue organization, extrapolated from large serial sections electron microscopy (ssEM) image data. We advocate the use of 3D immersive virtual reality (IVR) to facilitate the human analysis of such data. We have developed and evaluated the BrainTrek system - a CAVE-based IVR environment with a dedicated and intuitive user interface tailored to the investigation of neural tissue by scientists and educators.