7th IEEE International Conference on Bioinformatics and Bioengineering
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Abstract

Repeated sequences in genome are structures which indicate important biological functions such as protein binding. They are associated with various genetic diseases. We consider the problem of finding a specification for a "significant" repeating pattern in a given sequence. A significant pattern carries high amount of information, and it has many non-overlapping repeats. We propose for this problem, a method that takes as input an initial specification for a repeating pattern. A pattern is specified by a sequence of letters separated by varying length wildcards. The method presents to the user maximal occurrences for the current pattern specification in a way that no text symbol can be shared as a letter by two different pattern occurrences. This reduces the begin-end position-overlaps among different occurrences. The user modifies the specification manually to eliminate overlapping repeats. This process continues until a specification for a significant pattern is obtained.
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